Neuron loss in APP transgenic mice

被引：404

作者：

Calhoun, ME ^{[1
]}

Wiederhold, KH

Abramowski, D

Phinney, AL

Probst, A

Sturchler-Pierrat, C

Staufenbiel, M

Sommer, B

Jucker, M

机构：

[1] Univ Basel, Inst Pathol, CH-4003 Basel, Switzerland

[2] Novartis Pharma Ltd, Nervous Syst Res, CH-4002 Basel, Switzerland

来源：

NATURE | 1998年 / 395卷 / 6704期

关键词：

D O I：

10.1038/27351

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects a large proportion of the elderly population. Amyloid plaques, which are a neuro-pathological characteristic of AD, have been reproduced in transgenic mice by the overexpression of mutant forms of the amyloid-β precursor protein (APP) known to cause familial AD. Here we report that these mice exhibit selective neuronal death in the brain regions that are most affected in AD, suggesting that amyloid plaque formation is directly involved in AD neuron loss.

引用

页码：755 / 756

页数：2

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