A preliminary study of dopamine transporter binding in bipolar and unipolar depressed patients and healthy controls

被引:41
作者
Amsterdam, Jay D.
Newberg, Andrew B.
机构
[1] Univ Penn, Sch Med, Dept Psychiat, Depress Res Unit, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Radiol, Div Nucl Med, Philadelphia, PA 19104 USA
关键词
Tc-99m] TRODAT-1; single photon emission computed tomography; dopamine transporter; bipolar disorder; depression;
D O I
10.1159/000106476
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Objective: We examined striatal dopamine transporter (DAT) binding in bipolar and unipolar depressed patients and compared these values to those obtained from healthy control subjects using the selective DAT radioligand [Tc-99m]TRODAT-1 and single photon emission computed tomography imaging. We hypothesized that DAT levels might be higher in bipolar versus unipolar patients. Methods: [Tc-99m]TRODAT-1 scans were acquired from 5 bipolar and 10 unipolar patients and from 46 healthy controls. Distribution volume ratio (DVR) of [Tc-99m]TRODAT-1 binding affinity was calculated for regions of interest in the striatum. Results: Bipolar patients had greater DVR values compared to controls in the right posterior putamen (p = 0.001) and in the left caudate region (p = 0.007). Bipolar patients had modestly lower DAT binding in all brain regions examined, and a significantly lower DVR in the right caudate region compared to unipolar patients (p = 0.05). Conclusion: These data suggest that striatal DAT density may be increased in bipolar and unipolar depressed patients compared to controls, and that bipolar and unipolar depressed patients may have a different pattern of striatal DAT binding. Copyright (c) 2007 S. Karger AG, Basel.
引用
收藏
页码:167 / 170
页数:4
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