Recent improvements to the PROSITE database

被引:295
作者
Hulo, N
Sigrist, CJA
Le Saux, V
Langendijk-Genevaux, PS
Bordoli, L
Gattiker, A
De Castro, E
Bucher, P
Bairoch, A
机构
[1] Univ Geneva, CMU, SIB, CH-1211 Geneva 4, Switzerland
[2] Univ Basel, Biozentrum, SIB, CH-4056 Basel, Switzerland
[3] Swiss Inst Expt Canc Res, Swiss Inst Bioinformat, CH-1066 Epalinges, Switzerland
关键词
D O I
10.1093/nar/gkh044
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
The PROSITE database consists of a large collection of biologically meaningful signatures that are described as patterns or profiles. Each signature is linked to documentation that provides useful biological information on the protein family, domain or functional site identified by the signature. The PROSITE web page has been redesigned and several tools have been implemented to help the user discover new conserved regions in their own proteins and to visualize domain arrangements. We also introduced the facility to search PDB with a PROSITE entry or a user's pattern and visualize matched positions on 3D structures. The latest version of PROSITE (release 18.17 of November 30, 2003) contains 1676 entries. The database is accessible at http://www.expasy.org/prosite/.
引用
收藏
页码:D134 / D137
页数:4
相关论文
共 18 条
[1]
Apweiler R, 2004, NUCLEIC ACIDS RES, V32, pD115, DOI [10.1093/nar/gkw1099, 10.1093/nar/gkh131]
[2]
PRINTS and its automatic supplement, prePRINTS [J].
Attwood, TK ;
Bradley, P ;
Flower, DR ;
Gaulton, A ;
Maudling, N ;
Mitchell, AL ;
Moulton, G ;
Nordle, A ;
Paine, K ;
Taylor, P ;
Uddin, A ;
Zygouri, C .
NUCLEIC ACIDS RESEARCH, 2003, 31 (01) :400-402
[3]
A flexible motif search technique based on generalized profiles [J].
Bucher, P ;
Karplus, K ;
Moeri, N ;
Hofmann, K .
COMPUTERS & CHEMISTRY, 1996, 20 (01) :3-23
[4]
Profile hidden Markov models [J].
Eddy, SR .
BIOINFORMATICS, 1998, 14 (09) :755-763
[5]
The PROSITE database, its status in 2002 [J].
Falquet, L ;
Pagni, M ;
Bucher, P ;
Hulo, N ;
Sigrist, CJA ;
Hofmann, K ;
Bairoch, A .
NUCLEIC ACIDS RESEARCH, 2002, 30 (01) :235-238
[6]
Gattiker Alexandre, 2002, Appl Bioinformatics, V1, P107
[7]
GRIBSKOV M, 1990, METHOD ENZYMOL, V183, P146
[8]
Hofmann K, 2000, Brief Bioinform, V1, P167, DOI 10.1093/bib/1.2.167
[9]
PROTEIN-STRUCTURE COMPARISON BY ALIGNMENT OF DISTANCE MATRICES [J].
HOLM, L ;
SANDER, C .
JOURNAL OF MOLECULAR BIOLOGY, 1993, 233 (01) :123-138
[10]
Jonassen I, 1997, COMPUT APPL BIOSCI, V13, P509