Role of adapters in Toll-like receptor signalling

被引：42

作者：

Akira, S

Yamamoto, M

Takeda, K

机构：

[1] Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita, Osaka 5650871, Japan

[2] Japan Sci & Technol Corp, ERATO, Suita, Osaka 5650871, Japan

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2003年 / 31卷

关键词：

immune response; interleukin; interferon; Myd88; signal transduction; Toll-like receptor(TLR);

D O I：

10.1042/bst0310637

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Toll-like receptors (TLRs) play a critical role in the detection of invading pathogens within the body and the subsequent immune response. individual TLRs recognize distinct microbial components. The TLRs are a type 1 transmembrane receptor that possess an extracellular leucine-rich repeat domain and cytoplasmic domain homologous with that of the interleukin 1 receptor (IL-1R) family. Upon stimulation, TLR recruits the IL-1R-associated kinase (IRAK) via the adapter MyD88, ultimately leading to the activation of nuclear factor-kappaB. Cytokine production in response to all TLR ligands is completely abolished in MyD88-deficient cells, indicating that MyD88 is an essential signalling molecule shared among members of the IL-1R/Toll family. However, several novel adaptor molecules have recently been identified. Evidence is now accumulating showing that differential utilization of these adaptors may activate overlapping as well as distinct signalling pathways, and ultimately give rise to distinct biological effects exerted by individual TIER family members.

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收藏

页码：637 / 642

页数：6

相关论文

共 36 条

[1] Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function [J].

Adachi, O ;

Kawai, T ;

Takeda, K ;

Matsumoto, M ;

Tsutsui, H ;

Sakagami, M ;

Nakanishi, K ;

Akira, S .

IMMUNITY, 1998, 9 (01) :143-150

[2] Toll-like receptors in the induction of the innate immune response [J].

Aderem, A ;

Ulevitch, RJ .

NATURE, 2000, 406 (6797) :782-787

[3] Toll-like receptors: critical proteins linking innate and acquired immunity [J].

Akira, S ;

Takeda, K ;

Kaisho, T .

NATURE IMMUNOLOGY, 2001, 2 (08) :675-680

[4] Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 [J].

Alexopoulou, L ;

Holt, AC ;

Medzhitov, R ;

Flavell, RA .

NATURE, 2001, 413 (6857) :732-738

[5] Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2 [J].

Aliprantis, AO ;

Yang, RB ;

Mark, MR ;

Suggett, S ;

Devaux, B ;

Radolf, JD ;

Klimpel, GR ;

Godowski, P ;

Zychlinsky, A .

SCIENCE, 1999, 285 (5428) :736-739

[6] Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors [J].

Brightbill, HD ;

Libraty, DH ;

Krutzik, SR ;

Yang, RB ;

Belisle, JT ;

Bleharski, JR ;

Maitland, M ;

Norgard, MV ;

Plevy, SE ;

Smale, ST ;

Brennan, PJ ;

Bloom, BR ;

Godowski, PJ ;

Modlin, RL .

SCIENCE, 1999, 285 (5428) :732-736

[7] Activation of toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite [J].

Campos, MA ;

Almeida, IC ;

Takeuchi, O ;

Akira, S ;

Valente, EP ;

Procópio, DO ;

Travassos, LR ;

Smith, JA ;

Golenbock, DT ;

Gazzinelli, RT .

JOURNAL OF IMMUNOLOGY, 2001, 167 (01) :416-423

[8] Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction [J].

Fitzgerald, KA ;

Palsson-McDermott, EM ;

Bowie, AG ;

Jefferies, CA ;

Mansell, AS ;

Brady, G ;

Brint, E ;

Dunne, A ;

Gray, P ;

Harte, MT ;

McMurray, D ;

Smith, DE ;

Sims, JE ;

Bird, TA ;

O'Neill, LAJ .

NATURE, 2001, 413 (6851) :78-83

[9] The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5 [J].

Hayashi, F ;

Smith, KD ;

Ozinsky, A ;

Hawn, TR ;

Yi, EC ;

Goodlett, DR ;

Eng, JK ;

Akira, S ;

Underhill, DM ;

Aderem, A .

NATURE, 2001, 410 (6832) :1099-1103

[10] Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway [J].

Hemmi, H ;

Kaisho, T ;

Takeuchi, O ;

Sato, S ;

Sanjo, H ;

Hoshino, K ;

Horiuchi, T ;

Tomizawa, H ;

Takeda, K ;

Akira, S .

NATURE IMMUNOLOGY, 2002, 3 (02) :196-200

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