Role of urotensin II in patients on dialysis

被引：200

作者：

Totsune, K

Takahashi, K

Arihara, Z

Sone, M

Satoh, F

Ito, S

Kimura, Y

Sasano, H

Murakami, O

机构：

[1] Tohoku Univ, Sch Med, Dept Internal Med 2, Aoba Ku, Sendai, Miyagi 9808574, Japan

[2] Tohoku Univ, Sch Med, Dept Mol Biol, Aoba Ku, Sendai, Miyagi 9808574, Japan

[3] Tohoku Univ, Sch Med, Dept Pathol, Aoba Ku, Sendai, Miyagi 9808574, Japan

来源：

LANCET | 2001年 / 358卷 / 9284期

关键词：

D O I：

10.1016/S0140-6736(01)06002-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Urotensin II is a potent vasoconstrictor, which also has some vasodilatory properties. We Investigated Its expression In various tissues and In the plasma of patients with renal dysfunction. Plasma concentrations of urotensin II-like Immunoreactivity were 2-fold higher In patients not on dialysis and 3-fold higher In those on haemodialysis than In healthy Individuals. Messenger RNA encoding the urotensin II precursor and the urotensin II receptor precursor were expressed in various human tissues. The peptide might act as an Important regulator In the cardiovascular and renal systems. Urotensin II antagonists could, therefore, be useful In the treatment of diseases affecting these organs.

引用

页码：810 / 811

页数：2

共 5 条

[1] Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14 [J].

Ames, RS ;

Sarau, HM ;

Chambers, JK ;

Willette, RN ;

Alyar, NV ;

Romanic, AM ;

Louden, CS ;

Foley, JJ ;

Sauermelch, CF ;

Coatney, RW ;

Ao, ZH ;

Disa, J ;

Holmes, SD ;

Stadel, JM ;

Martin, JD ;

Liu, WS ;

Glover, GI ;

Wilson, S ;

McNulty, DE ;

Ellis, CE ;

Elshourbagy, NA ;

Shabon, U ;

Trill, JJ ;

Hay, DWP ;

Ohlstein, EH ;

Bergsma, DJ ;

Douglas, SA .

NATURE, 1999, 401 (6750) :282-286

[2] Human urotensin-II is an endothelium-dependent vasodilator in rat small arteries [J].

Bottrill, FE ;

Douglas, SA ;

Hiley, CR ;

White, R .

BRITISH JOURNAL OF PHARMACOLOGY, 2000, 130 (08) :1865-1870

[3] Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1 [J].

Maguire, JJ ;

Kuc, RE ;

Davenport, AP .

BRITISH JOURNAL OF PHARMACOLOGY, 2000, 131 (03) :441-446

[4] Potent vasodilator responses to human urotensin-II in human pulmonary and abdominal resistance arteries [J].

Stirrat, A ;

Gallagher, M ;

Douglas, SA ;

Ohlstein, EH ;

Berry, C ;

Kirk, A ;

Richardson, M ;

MacLean, MR .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 280 (02) :H925-H928

[5] DETECTION OF IMMUNOREACTIVE ENDOTHELIN IN PLASMA OF HEMODIALYSIS-PATIENTS [J].

TOTSUNE, K ;

MOURI, T ;

TAKAHASHI, K ;

OHNEDA, M ;

SONE, M ;

SAITO, T ;

YOSHINAGA, K .

FEBS LETTERS, 1989, 249 (02) :239-242

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