In vivo and in vitro antiinflammatory activity of saikosaponins

被引：165

作者：

Benito, PB ^{[1
]}

Martínez, MJA

Sen, AMS

Gómez, AS

Matellano, LF

Contreras, SS

Lanza, AMD

机构：

[1] Univ Complutense, Fac Pharm, Dept Pharmacol, E-28040 Madrid, Spain

[2] Univ Alcala de Henares, Fac Pharm, Dept Pharmacol, Madrid 28871, Spain

来源：

LIFE SCIENCES | 1998年 / 63卷 / 13期

关键词：

saikosaponins; antiinflammatory activity; PGE(2); LTC4; TXB2;

D O I：

10.1016/S0024-3205(98)00376-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Buddlejasaponin I and saikosaponin 1 and 2, biologically active compounds from Scrophularia scorodonia and Bupleurum rigidum respectively, exert potent in vivo antiinflammatory effects on mouse ear edema induced by phorbol myristate acetate (PMA). The effects of these compounds on swelling and other inflammatory parameters are described. In screening for in vitro effects of saikosaponins on cellular systems generating cyclooxygenase(COX) and lipoxygenase (LOX) metabolites, we observed that most saikosaponins showed a significant effect. The action is more marked on LOX metabolite LTC4 Our data support the inhibition of arachidonic acid metabolism as one of the biochemical mechanisms that might be the rationale for the putative antiphlogistic activity of these saikosaponins.

引用

页码：1147 / 1156

页数：10

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