Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat

被引：138

作者：

Jin, KL ^{[1
]}

Sun, YJ ^{[1
]}

Xie, L ^{[1
]}

Mao, XO ^{[1
]}

Childs, J ^{[1
]}

Peel, A ^{[1
]}

Logvinova, A ^{[1
]}

Banwait, S ^{[1
]}

Greenberg, DA ^{[1
]}

机构：

[1] Buck Inst Age Res, Novato, CA 94945 USA

来源：

NEUROBIOLOGY OF DISEASE | 2005年 / 18卷 / 02期

关键词：

doublecortin; ischemia; nestin; neural stein cells; neurogenesis; stroke; transplantation;

D O I：

10.1016/j.nbd.2004.10.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cell replacement therapy may have the potential to promote brain repair and recovery after stroke. To compare how focal cerebral ischemia affects the entry migration, and phenotypic features of neural precursor cells transplanted by different routes, we administered neuronal precursors from embryonic cerebral cortex of green fluorescent protein (GFP)-expressing transgenic mice to rats that had undergone middle cerebral artery occlusion (MCAO) by the intra-striatal, intraventricular, and intravenous routes. MCAO increased the entry of GFP-immunoreactive cells, most of which expressed neuroepithelial (nestin) or neuronal (doublecortin) markers, from the ventricles and bloodstream into the brain, and enhanced their migration when delivered by any of these routes. Transplanted neural precursors migrated into the ischemic striatum and cerebral cortex. Thus, transplantation of neural precursors by a variety of routes can deliver cells with the potential to replace injured neurons to ischemic brain regions. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：366 / 374

页数：9

共 36 条

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