Mechanisms for memory types differ

被引:225
作者
Izquierdo, I
Barros, DM
Souza, TME
de Souza, MM
Izquierdo, LA
Medina, JH
机构
[1] Univ Fed Rio Grande Sul, Inst Ciencias Basicas Saude, Dept Bioquim, BR-90035003 Porto Alegre, RS, Brazil
[2] Univ Buenos Aires, Fac Med, Inst Biol Celular Eduardo De Robertis, RA-1121 Buenos Aires, DF, Argentina
关键词
D O I
10.1038/31371
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The formation of long-term memory takes several hours1,2,3, during which time memories rely on short-term systems1,2,4,5. For over 100 years1, the main unanswered question of memory research has been whether short-term memory is a necessary step towards long-term memory4,5, or whether they are separate processes1,2. Here we report four treatments that block short-term memory while leaving long-term memory intact, showing that these memory systems are separate to some degree.
引用
收藏
页码:635 / 636
页数:2
相关论文
共 11 条
[1]   Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats [J].
Bernabeu, R ;
Bevilaqua, L ;
Ardenghi, P ;
Bromberg, E ;
Schmitz, P ;
Bianchin, M ;
Izquierdo, I ;
Medina, JH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (13) :7041-7046
[2]   Drugs acting upon the cyclic adenosine monophosphate protein kinase A signalling pathway modulate memory consolidation when given late after training into rat hippocampus but not amygdala [J].
Bevilaqua, L ;
Ardenghi, P ;
Schroder, N ;
Bromberg, E ;
Schmitz, PK ;
Schaeffer, E ;
Quevedo, J ;
Bianchin, M ;
Walz, R ;
Medina, JH ;
Izquierdo, I .
BEHAVIOURAL PHARMACOLOGY, 1997, 8 (04) :331-338
[3]  
Gold PE, 1975, SHORT TERM MEMORY, P355
[4]   Memory formation: The sequence of biochemical events in the hippocampus and its connection to activity in other brain structures [J].
Izquierdo, I ;
Medina, JH .
NEUROBIOLOGY OF LEARNING AND MEMORY, 1997, 68 (03) :285-316
[5]   Sequential role of hippocampus and amygdala, entorhinal cortex and parietal cortex in formation and retrieval of memory for inhibitory avoidance in rats [J].
Izquierdo, I ;
Quillfeldt, JA ;
Zanatta, MS ;
Quevedo, J ;
Schaeffer, E ;
Schmitz, PK ;
Medina, JH .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1997, 9 (04) :786-793
[6]  
IZQUIERDO I, MONAMINE INTERACTION
[7]  
James W., 1890, PRINCIPLES PSYCHOL, VII
[8]   AUTORADIOGRAPHIC ESTIMATION OF THE EXTENT OF REVERSIBLE INACTIVATION PRODUCED BY MICROINJECTION OF LIDOCAINE AND MUSCIMOL IN THE RAT [J].
MARTIN, JH .
NEUROSCIENCE LETTERS, 1991, 127 (02) :160-164
[9]  
Paxinos G., 1986, RAT BRAIN STEREOTAXI, Vsecond
[10]   SHORT-TERM, INTERMEDIATE-TERM, AND LONG-TERM MEMORIES [J].
ROSENZWEIG, MR ;
BENNETT, EL ;
COLOMBO, PJ ;
LEE, DW ;
SERRANO, PA .
BEHAVIOURAL BRAIN RESEARCH, 1993, 57 (02) :193-198