Selective versus total insulin resistance: A pathogenic paradox

被引：753

作者：

Brown, Michael S. ^{[1
]}

Goldstein, Joseph L. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Mol Genet, Dallas, TX 75390 USA

来源：

CELL METABOLISM | 2008年 / 7卷 / 02期

关键词：

D O I：

10.1016/j.cmet.2007.12.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mice with type 2 diabetes manifest selective hepatic insulin resistance: insulin fails to suppress gluconeogenesis but continues to activate lipogenesis, producing the deadly combination of hyperglycemia and hypertriglyceridemia. In this issue of Cell Metabolism, Biddinger et al. (2008) show that mice with total hepatic insulin resistance exhibit hyperglycemia without hypertriglyceridemia-a state paradoxically less severe than selective insulin resistance.

引用

页码：95 / 96

页数：2

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