Platelet factor 4: a chemokine enigma

被引：66

作者：

Slungaard, A

机构：

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2005年 / 37卷 / 06期

关键词：

platelet factor 4; thrombosis; protein C; thrombomodulin;

D O I：

10.1016/j.biocel.2004.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Platelet factor 4 (PF4) is a platelet a-granule protein sequenced over 25 years ago that is a founding member of the C-X-C chemokine family, yet its physiologic function has yet to be definitively established. Initial investigations focused on possible procoagulant roles for PF4 in platelet function and plasmatic coagulation. Subsequent in vitro studies have, however, described a puzzling array of other apparently unrelated biologic functions, including inhibition of angiogenesis and hematopoiesis, promotion of neutrophil adhesion, and activation, enhancement of oxy-LDL binding to the LDL receptor and stimulation of anti-coagulant activated protein C generation by the thrombomodulin/protein C system. Preliminary studies with a just-described PF4 knockout mouse line support a role for PF4 in platelet-depen dent thrombosis in vivo. (c) 2004 Elsevier Ltd. All rights reserved.

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页码：1162 / 1167

页数：6

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