Exposure Assessment in Cohort Studies of Childhood Asthma

被引:15
作者
Arrandale, Victoria H. [2 ]
Brauer, Michael [3 ]
Brook, Jeffrey R. [1 ,2 ]
Brunekreef, Bert [4 ]
Gold, Diane R. [5 ]
London, Stephanie J. [6 ]
Miller, J. David [7 ]
Oezkaynak, Haluk [8 ]
Ries, Nola M. [9 ,10 ,11 ]
Sears, Malcolm R. [12 ]
Silverman, Frances S. [2 ]
Takaro, Tim K. [13 ]
机构
[1] Environm Canada, Air Qual Res Div, Toronto, ON M3H 5T4, Canada
[2] Univ Toronto, Dalla Lana Sch Publ Hlth, Gage Occupat & Environm Hlth Unit, Toronto, ON, Canada
[3] Univ British Columbia, Sch Environm Hlth, Vancouver, BC V5Z 1M9, Canada
[4] Univ Utrecht, Inst Risk Assessment Sci, Div Environm Epidemiol, Utrecht, Netherlands
[5] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA
[6] NIEHS, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA
[7] Carleton Univ, Coll Nat Sci, Ottawa, ON K1S 5B6, Canada
[8] US EPA, Res Triangle Pk, NC 27711 USA
[9] Univ Alberta, Hlth Law Inst, Edmonton, AB, Canada
[10] Univ Victoria, Fac Law, Victoria, BC, Canada
[11] Univ Victoria, Sch Hlth Informat Sci, Victoria, BC, Canada
[12] McMaster Univ, Firestone Inst Resp Hlth, Hamilton, ON, Canada
[13] Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC V5A 1S6, Canada
关键词
childhood asthma; cohort studies; exposure assessment; GENE-ENVIRONMENT INTERACTION; GERMAN MULTICENTER ALLERGY; PIAMA BIRTH COHORT; IN-HOUSE DUST; AIR-POLLUTION; TOBACCO-SMOKE; INDOOR AIR; EARLY-LIFE; BRONCHIAL OBSTRUCTION; HOME CHARACTERISTICS;
D O I
10.1289/ehp.1002267
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
BACKGROUND: The environment is suspected to play an important role in the development of childhood asthma. Cohort studies are a powerful observational design for studying exposure-response relationships, but their power depends in part upon the accuracy of the exposure assessment. OBJECTIVE: The purpose of this paper is to summarize and discuss issues that make accurate exposure assessment a challenge and to suggest strategies for improving exposure assessment in longitudinal cohort studies of childhood asthma and allergies. DATA SYNTHESIS: Exposures of interest need to be prioritized, because a single study cannot measure all potentially relevant exposures. Hypotheses need to be based on proposed mechanisms, critical time windows for effects, prior knowledge of physical, physiologic, and immunologic development, as well as genetic pathways potentially influenced by the exposures. Modifiable exposures are most important from the public health perspective. Given the interest in evaluating gene-environment interactions, large cohort sizes are required, and planning for data pooling across independent studies is critical. Collection of additional samples, possibly through subject participation, will permit secondary analyses. Models combining air quality, environmental, and dose data provide exposure estimates across large cohorts but can still be improved. CONCLUSIONS: Exposure is best characterized through a combination of information sources. Improving exposure assessment is critical for reducing measurement error and increasing power, which increase confidence in characterization of children at risk, leading to improved health outcomes.
引用
收藏
页码:591 / 597
页数:7
相关论文
共 99 条
[1]   Direct and indirect exposure to pets - risk of sensitization and asthma at 4 years in a birth cohort [J].
Almqvist, C ;
Egmar, AC ;
Hedlin, G ;
Lundqvist, M ;
Nordvall, SL ;
Pershagen, G ;
Svartengren, M ;
van Hage-Hamsten, M ;
Wickman, M .
CLINICAL AND EXPERIMENTAL ALLERGY, 2003, 33 (09) :1190-1197
[2]  
[Anonymous], 2009, Modern epidemiology
[3]   Feasibility of using subject-collected dust samples in epidemiologic and clinical studies of indoor allergens [J].
Arbes, SJ ;
Sever, M ;
Vaughn, B ;
Mehta, J ;
Lynch, JT ;
Mitchell, H ;
Hoppin, JA ;
Spencer, HL ;
Sandler, DP ;
Zeldin, DC .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2005, 113 (06) :665-669
[4]   Optimizing power in allocating resources to exposure assessment in an epidemiologic study [J].
Armstrong, BG .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1996, 144 (02) :192-197
[5]   EFFECT OF ALLERGEN AVOIDANCE ON DEVELOPMENT OF ALLERGIC DISORDERS IN INFANCY [J].
ARSHAD, SH ;
MATTHEWS, S ;
GANT, C ;
HIDE, DW .
LANCET, 1992, 339 (8808) :1493-1497
[6]   Rapid DNA Methylation Changes after Exposure to Traffic Particles [J].
Baccarelli, Andrea ;
Wright, Robert O. ;
Bollati, Valentina ;
Tarantini, Letizia ;
Litonjua, Augusto A. ;
Suh, Helen H. ;
Zanobetti, Antonella ;
Sparrow, David ;
Vokonas, Pantel S. ;
Schwartz, Joel .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 179 (07) :572-578
[7]   The Canadian asthma primary prevention study: Outcomes at 2 years of age [J].
Becker, A ;
Watson, W ;
Ferguson, A ;
Dimich-Ward, H ;
Chan-Yeung, M .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 113 (04) :650-656
[8]   Breast-feeding and environmental tobacco smoke exposure [J].
Becker, AB ;
Manfreda, J ;
Ferguson, AC ;
Dimich-Ward, H ;
Watson, WTA ;
Chan-Yeung, M .
ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE, 1999, 153 (07) :689-691
[9]   Gender differences in airway behaviour over the human life span [J].
Becklake, MR ;
Kauffmann, F .
THORAX, 1999, 54 (12) :1119-1138
[10]  
Bernstein D.I., 2006, Asthma in the workplace, V3rd, P1