ABCA1-deficient mice - Insights into the role of monocyte lipid efflux in HDL formation and inflammation

被引：128

作者：

Aiello, RJ ^{[1
]}

Brees, D ^{[1
]}

Francone, OL ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Dept Cardiovasc & Metab Dis, Groton, CT 06340 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2003年 / 23卷 / 06期

关键词：

Tangier disease; ATP-binding cassette transporter A1; cholesterol efflux; HDL; macrophages; atherosclerosis;

D O I：

10.1161/01.ATV.0000054661.21499.FB

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Studies with ATP-binding cassette transporter (ABCA1)-deficient mice have been critical in demonstrating the relation between ABCA1 expression, cellular lipid efflux, and HDL metabolism. The phenotype of the ABCA1-deficient mouse parallels the phenotype observed in human Tangier disease, including substantial reductions in both apolipoprotein B and apolipoprotein AI with confounding affects on atherosclerosis.

引用

页码：972 / 980

页数：9

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