The effect of flurbiprofen and tiaprofenic acid on serum cytokine levels of patients with osteoarthrosis

被引：8

作者：

Uzun, H

Tuzun, S

Ozaras, N

Aydin, S

Ozaras, R

Dondurmaci, S

Tuzun, F

机构：

[1] Univ Istanbul, Cerahpasa Med Fac, Istanbul, Turkey

[2] Univ Istanbul, Vakif Gureba Hosp, Istanbul, Turkey

来源：

ACTA ORTHOPAEDICA SCANDINAVICA | 2001年 / 72卷 / 05期

关键词：

D O I：

10.1080/000164701753532844

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

39 patients with active knee osteoarthrosis, chosen according to ACR criteria, were assigned to receive flurbiprofen (n 12, 2 x 100 mg), tiaprofenic acid (n 14, 2 x 300 mg) and placebo (n 13) in a 3-week, placebo-controlled study. All patients completed the study, and both medications were found to be effective: improvement occurred in the clinical signs. These drugs reduced the TNF-a levels. Flurbiprofen especially affected the IL-6 levels. Our findings indicate that NSAIDs may be effective in the etiopathogenesis of osteoarthrosis.

引用

页码：499 / 502

页数：4

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