Direct formation of 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose 5-phosphate by 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a new enzyme in the non-mevalonate pathway to isopentenyl diphosphate

被引：154

作者：

Kuzuyama, T ^{[1
]}

Takahashi, S ^{[1
]}

Watanabe, H ^{[1
]}

Seto, H ^{[1
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 25期

关键词：

biosynthesis; isopentenyl diphosphate; 2-C-methyl-D-erythritol; 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase;

D O I：

10.1016/S0040-4039(98)00802-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-Deoxy-D-xylulose 5-phosphate is biotransformed to 2-C-methyl-D-erythritol 4-phosphate in a single step in die presence of NADPH by a new recombinant enzyme named I-deoxy-D-xylulose 5-phosphate reductoisomerase purified from Escherichia coli. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4509 / 4512

页数：4

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