Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance

被引：188

作者：

Makrigiannakis, A ^{[1
]}

Zoumakis, E

Kalantaridou, S

Coutifaris, C

Margioris, AN

Coukos, G

Rice, KC

Gravanis, A

Chrousos, GP

机构：

[1] Univ Crete, Sch Med, Iraklion 71110, Greece

[2] Hammersmith Hosp, Imperial Coll Sch Sci & Med, Dept Reprod Med, IVF Unit, London W12, England

[3] Onassis Fdn, Athens, Greece

[4] Univ Penn, Med Ctr, Dept Obstet & Gynecol, Philadelphia, PA 19104 USA

[5] NICHHD, Pediat & Reprod Endocrinol Branch, Bethesda, MD 20892 USA

[6] NIDDKD, Med Chem Lab, Bethesda, MD 20892 USA

来源：

NATURE IMMUNOLOGY | 2001年 / 2卷 / 11期

关键词：

D O I：

10.1038/ni719

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The semi-allograft embryo in the blastocyst stage implants itself in the endometrium, yet no immune rejection processes are activated. Embryonic trophoblast and maternal decidua produce corticotropin-releasing hormone (CRH) and express Fas ligand (FasL), a proapoptotic cytokine. We found that antalarmin, a CRH receptor type I antagonist, decreased FasL expression and promoted apoptosis of activated T lymphocytes, an effect which was potentiated by CRH and inhibited by antalarmin. Female rats treated with antalarmin showed a marked decrease in implantation sites and live embryos and diminished endometrial FasL expression. Embryos from mothers that lacked T cells or from syngeneic matings were not rejected when the mothers were given antalarmin. These findings suggested that locally produced CRH promotes implantation and maintenance of early pregnancy primarily by killing activated T cells.

引用

页码：1018 / 1024

页数：7

共 54 条

[1] Effects of human trophoblast-induced interferons on the expression of proto-oncogenes c-fms/CSF-1R, EGF-R and c-erbB2 in invasive and non-invasive trophoblast [J].