Curing metastatic cancer:: Lessons from testicular germ-cell tumours

被引：175

作者：

Masters, JRW

Köberle, B

机构：

[1] UCL, Inst Urol, Prostate Canc Res Ctr, London W1W 7EJ, England

[2] Univ Pittsburgh, Inst Canc, Hillman Canc Ctr, Pittsburgh, PA 15213 USA

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 07期

关键词：

D O I：

10.1038/nrc1120

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Most metastatic cancers are fatal. More than 80% of patients with metastatic testicular germ-cell tumours (TGCTs), however, can be cured using cisplatin-based combination chemotherapy. Why are TGCTs more sensitive to chemotherapeutics than most other tumour types? Answers to this question could lead to new treatments for metastatic cancers.

引用

页码：517 / 525

页数：9

共 80 条

[1] Bcl-2 overexpression results in reciprocal downregulation of Bcl-XL and sensitizes human testicular germ cell tumours to chemotherapy-induced apoptosis [J].