Iron homeostasis: Fitting the puzzle pieces together

被引：91

作者：

Ganz, Tomas ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

CELL METABOLISM | 2008年 / 7卷 / 04期

关键词：

D O I：

10.1016/j.cmet.2008.03.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Here, recent insights into iron homeostasis are highlighted. Three studies demonstrate the importance of the IRE-IRP system for enterocytes in balancing extracellular iron demand against cellular iron requirements, show that the hemochromatosis protein HFE exerts its iron-regulatory activity principally in hepatocytes by modulating the production of hepcidin, and provide strong support for a proposed mechanism of transcriptional regulation of hepcidin through a signaling cascade initiated by holotransferrin displacing HFE from transferrin receptor 1.

引用

收藏

页码：288 / 290

页数：3

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