Lycopene oxidation product enhances gap junctional communication

被引：118

作者：

Aust, O

Ale-Agha, N

Zhang, L

Wollersen, H

Sies, H

Stahl, W

机构：

[1] Univ Dusseldorf, Inst Biochem & Mol Biol 1, D-40001 Dusseldorf, Germany

[2] Univ Gesamthsch Paderborn, Fachbereich Chem & Chem Tech 13, D-33098 Paderborn, Germany

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2003年 / 41卷 / 10期

关键词：

carotenoids; lycopene oxidation product; gap junctional communication;

D O I：

10.1016/S0278-6915(03)00148-0

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Carotenoids as well as their metabolites and oxidation products stimulate gap junctional communication (GJC) between cells, which is thought to be one of the protective mechanisms related to cancer-preventive activities of these compounds. Increased intake of lycopene by consumption of tomatoes or tomato products has been epidemiologically associated with a diminished risk of prostate cancer. Here, we report a stimulatory effect of a lycopene oxidation product on GJC in rat liver epithelial WB-F344 cells. The active compound was obtained by complete in vitro oxidation of lycopene with hydrogen peroxide/osmium tetroxide. For structural analysis high performance liquid chromatography, gas chromatography coupled with mass spectrometry, ultraviolet/visible-, and infrared spectrophotometry were applied. The biologically active oxidation product was identified as 2,7,1 1-trimethyltetradecahexaene-1, 14-dial. The present data indicate a potential role of lycopene degradation products in cell signaling enhancing cell-to-cell communication via gap junctions. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1399 / 1407

页数：9

共 32 条

[1] (-)-Epicatechin effects in rat liver epithelial cells:: stimulation of gap junctional communication and counteraction of its loss due to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate [J].