PTPRC (CD45) is not associated with the development of multiple sclerosis in US patients

被引：55

作者：

Barcellos, LF

Caillier, S

Dragone, L

Elder, M

Vittinghoff, E

Bucher, P

Lincoln, RR

Pericak-Vance, M

Haines, JL

Weiss, A

Hauser, SL

Oksenberg, JR

机构：

[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[6] Duke Univ, Med Ctr, Dept Med, Ctr Human Genet, Durham, NC USA

[7] Vanderbilt Univ, Dept Mol Physiol & Biophys, Program Human Genet, Nashville, TN 37232 USA

来源：

NATURE GENETICS | 2001年 / 29卷 / 01期

关键词：

D O I：

10.1038/ng722

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A C-->G nucleotide transition in exon 4 of PTPRC (encoding protein-tyrosine phosphatase receptor-type C, also known as CD45) was recently reported to be genetically associated with the development of multiple sclerosis (MS)(1). We performed an extensive evaluation of this polymorphism using large family-based and case-control comparisons. Overall, we observed no evidence of genetic association between the PTPRC polymorphism and MS susceptibility or disease course.

引用

页码：23 / 24

页数：2

共 9 条

[1]

BARCELLOS LF, IN PRESS BRAIN

[2] Apolipoprotein E variation at the sequence haplotype level:: Implications for the origin and maintenance of a major human polymorphism [J].