Mena, a relative of VASP and Drosophila enabled, is implicated in the control of microfilament dynamics

被引：565

作者：

Gertler, FB

Niebuhr, K

Reinhard, M

Wehland, J

Soriano, P

机构：

[1] GESELL BIOTECHNOL FORSCH MBH, D-38124 BRAUNSCHWEIG, GERMANY

[2] UNIV WURZBURG, MED KLIN, D-97080 WURZBURG, GERMANY

来源：

CELL | 1996年 / 87卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0092-8674(00)81341-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Drosophila Enabled is required for proper formation of axonal structures and is genetically implicated in signaling pathways mediated by Drosophila Abl. We have identified two murine proteins, Mena and Evl, that are highly related to Enabled as well as VASP (Vasodilator-Stimulated Phosphoprotein). A conserved domain targets Mena to localized proteins containing a specific proline-rich motif. The association of Mena with the surface of the intracellular pathogen Listeria monocytogenes and the G-actin binding protein profilin suggests that this molecule may participate in bacterial movement by facilitating actin polymerization. Expression of neural-enriched isoforms of Mena in fibroblasts induces the formation of abnormal F-actin-rich outgrowths, supporting a role for this protein in microfilament assembly and cell motility.

引用

页码：227 / 239

页数：13

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[1] SH3 DOMAINS DIRECT CELLULAR-LOCALIZATION OF SIGNALING MOLECULES [J].