Identification of potent and novel small-molecule inhibitors of caspase-3

被引：23

作者：

Allen, DA ^{[1
]}

Pham, P ^{[1
]}

Choong, IC ^{[1
]}

Fahr, B ^{[1
]}

Burdett, MT ^{[1
]}

Lew, W ^{[1
]}

DeLano, WL ^{[1
]}

Gordon, EM ^{[1
]}

Lam, JW ^{[1
]}

O'Brien, T ^{[1
]}

Lee, D ^{[1
]}

机构：

[1] Sunesis Pharmaceut Inc, San Francisco, CA 94080 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 21期

关键词：

D O I：

10.1016/j.bmcl.2003.08.024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：3651 / 3655

页数：5

共 18 条

[1]

CAI SX, 2000, Patent No. 6153591

[2] Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design [J].

Choong, IC ;

Lew, W ;

Lee, D ;

Pham, P ;

Burdett, MT ;

Lam, JW ;

Wiesmann, C ;

Luong, TN ;

Fahr, B ;

DeLano, WL ;

McDowell, RS ;

Allen, DA ;

Erlanson, DA ;

Gordon, EM ;

O'Brien, T .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (23) :5005-5022

[3]

*DEL SCI LLC, GRAPH PROD PYMOL V 0

[4] Caspases: Keys in the ignition of cell death [J].

Denault, JB ;

Salvesen, GS .

CHEMICAL REVIEWS, 2002, 102 (12) :4489-4499

[5] Mammalian caspases: Structure, activation, substrates, and functions during apoptosis [J].

Earnshaw, WC ;

Martins, LM ;

Kaufmann, SH .

ANNUAL REVIEW OF BIOCHEMISTRY, 1999, 68 :383-424

[6] In situ assembly of enzyme inhibitors using extended tethering [J].

Erlanson, DA ;

Lam, JW ;

Wiesmann, C ;

Luong, TN ;

Simmons, RL ;

DeLano, WL ;

Choong, IC ;

Burdett, MT ;

Flanagan, WM ;

Lee, D ;

Gordon, EM ;

O'Brien, T .

NATURE BIOTECHNOLOGY, 2003, 21 (03) :308-314

[7]

GARVEY EP, 1994, J BIOL CHEM, V269, P26669

[8]

IDUN PHARM INC, 2000, Patent No. [00023421, 0023421]

[9] Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase [J].

Jones, TR ;

Varney, MD ;

Webber, SE ;

Lewis, KK ;

Marzoni, GP ;

Palmer, CL ;

Kathardekar, V ;

Welsh, KM ;

Webber, S ;

Matthews, DA ;

Appelt, K ;

Smith, WW ;

Janson, CA ;

Villafranca, JE ;

Bacquet, RJ ;

Howland, EF ;

Booth, CLJ ;

Herrmann, SM ;

Ward, RW ;

White, J ;

Moomaw, EW ;

Bartlett, CA ;

Morse, CA .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (04) :904-917

[10] Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidic heterocycles as novel tetrazole bioisosteres [J].

Kohara, Y ;

Kubo, K ;

Imamiya, E ;

Wada, T ;

Inada, Y ;

Naka, T .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (26) :5228-5235

← 1 2 →