Physiological regulation of uteroglobin/CCSP expression

被引：23

作者：

Chang, A

Ramsay, P

Zhao, BH

Park, M

Magdaleno, S

Reardon, MJ

Welty, S

DeMayo, FJ

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Surg, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[4] Baylor Coll Med, Houston, TX 77030 USA

[5] St Jude Childrens Res Hosp, Dept Dev Neurobiol, Memphis, TN 38105 USA

来源：

UTEROGLOBIN/CLARA CELL PROTEIN FAMILY | 2000年 / 923卷

关键词：

D O I：

10.1111/j.1749-6632.2000.tb05529.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Uteroglobin/CCSP is expressed specifically in the Clara cells. This allows the gene to be used as a marker to identify the elements regulating the physiologic and cell-specific expression of this gene. The regulation of UG/CCSP by IFN-gamma was shown to be at the level of the proximal promoter by the upregulation of HNF3 beta. This has allowed the determination of the factors responsible for the expression of UG/CCSP.

引用

页码：181 / 192

页数：12

共 61 条

[1] PURIFICATION AND LEVEL OF EXPRESSION IN BRONCHOALVEOLAR LAVAGE OF A HUMAN POLYCHLORINATED BIPHENYL (PCB)-BINDING PROTEIN - EVIDENCE FOR A STRUCTURAL AND FUNCTIONAL KINSHIP TO THE MULTIHORMONALLY REGULATED PROTEIN UTEROGLOBIN [J].