Active infection with Helicobacter pylori in healthy couples

被引:38
作者
Brenner, H
Rothenbacher, D
Bode, G
Dieudonné, P
Adler, G
机构
[1] Univ Ulm, Dept Epidemiol, D-89069 Ulm, Germany
[2] Univ Ulm, Dept Internal Med 1, D-89069 Ulm, Germany
关键词
D O I
10.1017/S0950268898001964
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The mode of spread of Helicobacter pylori infection is subject to ongoing debate. Recent studies among patients with gastrointestinal disorders suggest a potential role of conjugal transmission. In this study, the clustering of H. pylori infection was assessed among 110 employees of a health insurance company and their partners. Active infection with H. pylori was measured by the C-13-urea breath test. Information on potential confounders was collected by a standardized questionnaire. Overall, 16 employees (14.5 %) and 24 partners (21.8 %) were infected. While only 7% (6/86) of employees with an uninfected partner were infected, this applied to 42 % (10/24) of employees with an infected partner. A very strong relation between partners' infection status persisted after control for age and other potential confounders (adjusted odds ratio, 7.0; 95% confidence interval, 1.8-26.7). Furthermore, the risk of infection increased with the number of years lived with an infected partner. These results support the hypothesis of a major role of spouse-to-spouse transmission of H. pylori infection.
引用
收藏
页码:91 / 95
页数:5
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