Structural genomics: keystone for a Human Proteome Project

被引:98
作者
Montelione, GT [1 ]
Anderson, S
机构
[1] Rutgers State Univ, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA
[2] Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA
关键词
D O I
10.1038/4878
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A natural extension of the genome sequencing projects involves analysis of the corresponding three dimensional protein structures. This emerging field of 'structural genomics' has the potential to unify our understanding of the structural basis of protein function.
引用
收藏
页码:11 / 12
页数:2
相关论文
共 9 条
[1]   Structural genomics: Bioinformatics in the driver's seat [J].
Gaasterland, T .
NATURE BIOTECHNOLOGY, 1998, 16 (07) :625-627
[2]   Phase determination from multiwavelength anomalous diffraction measurements [J].
Hendrickson, WA ;
Ogata, CM .
MACROMOLECULAR CRYSTALLOGRAPHY, PT A, 1997, 276 :494-523
[3]   Shining a light on structural genomics [J].
Kim, SH .
NATURE STRUCTURAL BIOLOGY, 1998, 5 (Suppl 8) :643-645
[4]   X-ray crystallography - Taking a structured approach to understanding proteins [J].
Pennisi, E .
SCIENCE, 1998, 279 (5353) :978-979
[5]   100,000 protein structures for the biologist [J].
Andrej Šali .
Nature Structural Biology, 1998, 5 (12) :1029-1032
[6]   The Argonne Structural Genomics Workshop: Lamaze class for the birth of a new science [J].
Shapiro, L ;
Lima, CD .
STRUCTURE, 1998, 6 (03) :265-267
[7]   Class-directed structure determination: Foundation for a protein structure initiative [J].
Terwilliger, TC ;
Waldo, G ;
Peat, TS ;
Newman, JM ;
Chu, K ;
Berendzen, J .
PROTEIN SCIENCE, 1998, 7 (09) :1851-1856
[8]   Lessons learned, promises kept: A biologist's eye view of the genome project [J].
Tilghman, SM .
GENOME RESEARCH, 1996, 6 (09) :773-780
[9]   The second decade -: into the third millennium [J].
Wüthrich, K .
NATURE STRUCTURAL BIOLOGY, 1998, 5 (Suppl 7) :492-495