The nuclear receptor PPARγ -: bigger than fat

被引：126

作者：

Kliewer, SA

Willson, TM

机构：

[1] Glaxo Wellcome Res & Dev Ltd, Dept Mol Endocrinol, Res Triangle Pk, NC 27709 USA

[2] Glaxo Wellcome Res & Dev Ltd, Dept Med Chem, Res Triangle Pk, NC 27709 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1998年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0959-437X(98)80014-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Work reported over the past year has provided insights into the mechanisms whereby ligand activation of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR gamma) regulates systemic glucose and lipid homeostasis. PPAR gamma has also been implicated recently in the biology of monocytes and in cell-cycle regulation and cancer. Polyunsaturated fatty acids and eicosanoids bind and activate PPAR gamma, suggesting that these lipids may serve as hormonal regulators of a variety of biological processes.

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收藏

页码：576 / 581

页数：6

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