Naphthoquinone analogs as inactivators of cdc25 phosphatase

被引：51

作者：

Ham, SW ^{[1
]}

Park, J

Lee, SJ

Kim, W

Kang, K

Choi, KH

机构：

[1] Chung Ang Univ, Dept Chem, Seoul 156756, South Korea

[2] Chung Ang Univ, Dept Biol, Seoul 156756, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 18期

基金：

新加坡国家研究基金会;

关键词：

enzyme inhibitors; quinones;

D O I：

10.1016/S0960-894X(98)00411-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

cdc25A and cdc25B were significantly overexpressed in certain types of cancers, and they represent potential therapeutic targets for anticancer drug. In this study, naphthoquinone analogs as cdc25A phosphatase inactivators were investigated. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2507 / 2510

页数：4

共 16 条

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[2]

BTOEN PC, 1991, ARCH BIOCHEM BIOPHYS, V285, P187

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