Genomic microarrays in human genetic disease and cancer

被引：265

作者：

Albertson, DG

Pinkel, D

机构：

[1] Univ Calif San Francisco, Canc Res Inst, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA

来源：

HUMAN MOLECULAR GENETICS | 2003年 / 12卷

关键词：

D O I：

10.1093/hmg/ddg261

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alterations in the genome that lead to changes in DNA sequence copy number are a characteristic of solid tumors and are found in association with developmental abnormalities and/or mental retardation. Comparative genomic hybridization (CGH) can be used to detect and map these changes. Recent improvements in the resolution and sensitivity of CGH have been possible through implementation of microarray-based CGH (array CGH). Here we discuss the performance characteristics of different array platforms and review some of the recent applications of array CGH in cancer and medical genetics.

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页码：R145 / R152

页数：8

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