Visual transduction in Drosophila

被引:384
作者
Hardie, RC [1 ]
Raghu, P [1 ]
机构
[1] Univ Cambridge, Dept Anat, Cambridge CB2 3DY, England
关键词
D O I
10.1038/35093002
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The brain's capacity to analyse and interpret information is limited ultimately by the input it receives. This sets a premium on information capacity of sensory receptors, which can be maximized by optimizing sensitivity, speed and reliability of response. Nowhere is selection pressure for information capacity stronger than in the visual system, where speed and sensitivity can mean the difference between life and death. Phototransduction in flies represents the fastest G-protein-signalling cascade known. Analysis in Drosophila has revealed many of the underlying molecular strategies, leading to the discovery and characterization of signalling molecules of widespread importance.
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收藏
页码:186 / 193
页数:8
相关论文
共 95 条
[1]   InsP(3) receptor is essential for growth and differentiation but not for vision in Drosophila [J].
Acharya, JK ;
Jalink, K ;
Hardy, RW ;
Hartenstein, V ;
Zuker, CS .
NEURON, 1997, 18 (06) :881-887
[2]   LOW RETINAL NOISE IN ANIMALS WITH LOW BODY-TEMPERATURE ALLOWS HIGH VISUAL SENSITIVITY [J].
AHO, AC ;
DONNER, K ;
HYDEN, C ;
LARSEN, LO ;
REUTER, T .
NATURE, 1988, 334 (6180) :348-350
[3]   The visual G protein of fly photoreceptors interacts with the PDZ domain assembled INAD signaling complex via direct binding of activated Gαq to phospholipase Cβ [J].
Bähner, M ;
Sander, P ;
Paulsen, R ;
Huber, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (04) :2901-2904
[4]  
BAYLOR DA, 1979, J PHYSIOL-LONDON, V288, P613
[5]   ISOLATION OF A PUTATIVE PHOSPHOLIPASE-C GENE OF DROSOPHILA, NORPA, AND ITS ROLE IN PHOTOTRANSDUCTION [J].
BLOOMQUIST, BT ;
SHORTRIDGE, RD ;
SCHNEUWLY, S ;
PERDEW, M ;
MONTELL, C ;
STELLER, H ;
RUBIN, G ;
PAK, WL .
CELL, 1988, 54 (05) :723-733
[6]   REGULATORY ARRESTIN CYCLE SECURES THE FIDELITY AND MAINTENANCE OF THE FLY PHOTORECEPTOR CELL [J].
BYK, T ;
BARYAACOV, M ;
DOZA, YN ;
MINKE, B ;
SELINGER, Z .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (05) :1907-1911
[7]   Membrane protein diffusion sets the speed of rod phototransduction [J].
Calvert, PD ;
Govardovskii, VI ;
Krasnoperova, N ;
Anderson, RE ;
Lem, J ;
Makino, CL .
NATURE, 2001, 411 (6833) :90-94
[8]   MECHANISMS OF RHODOPSIN INACTIVATION IN-VIVO AS REVEALED BY A COOH-TERMINAL TRUNCATION MUTANT [J].
CHEN, J ;
MAKINO, CL ;
PEACHEY, NS ;
BAYLOR, DA ;
SIMON, MI .
SCIENCE, 1995, 267 (5196) :374-377
[9]   Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex [J].
Chevesich, J ;
Kreuz, AJ ;
Montell, C .
NEURON, 1997, 18 (01) :95-105
[10]   Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition [J].
Chuang, HH ;
Prescott, ED ;
Kong, HY ;
Shields, S ;
Jordt, SE ;
Basbaum, AI ;
Chao, MV ;
Julius, D .
NATURE, 2001, 411 (6840) :957-962