Helminth infections: the great neglected tropical diseases

被引：1060

作者：

Hotez, Peter J. ^{[1
]}

Brindley, Paul J. ^{[1
]}

Bethony, Jeffrey M. ^{[1
]}

King, Charles H. ^{[2
]}

Pearce, Edward J. ^{[3
]}

Jacobson, Julie ^{[4
]}

机构：

[1] George Washington Univ, Sch Med & Hlth Sci, Dept Microbiol Immunol & Trop Med, Washington, DC 20037 USA

[2] Case Western Reserve Univ, Sch Med, Ctr Global Hlth & Dis, Cleveland, OH USA

[3] Univ Penn, Dept Pathobiol, Philadelphia, PA 19104 USA

[4] Bill & Melinda Gates Fdn, Seattle, WA USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2008年 / 118卷 / 04期

关键词：

D O I：

10.1172/JCI34261

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Helminths are parasitic worms. They are the most common infectious agents of humans in developing countries and produce a global burden of disease that exceeds better-known conditions, including malaria and tuberculosis. As we discuss here, new insights into fundamental helminth biology are accumulating through newly completed genome projects and the nascent application of transgenesis and RNA interference technologies. At the same time, our understanding of the dynamics of the transmission of helminths and the mechanisms of the Th2-type immune responses that are induced by infection with these parasitic worms has increased markedly. Ultimately, these advances in molecular and medical helminth biology should one day translate into a new and robust pipeline of drugs, diagnostics, and vaccines for targeting parasitic worms that infect humans.

引用

页码：1311 / 1321

页数：11

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