HIV-1 regulatory/accessory genes: Keys to unraveling viral and host cell biology

被引：295

作者：

Emerman, M

Malim, MH

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Mol Med, Seattle, WA 98109 USA

[2] Univ Penn, Howard Hughes Med Inst, Dept Microbiol, Philadelphia, PA 19104 USA

来源：

SCIENCE | 1998年 / 280卷 / 5371期

关键词：

D O I：

10.1126/science.280.5371.1880

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human immunodeficiency virus type-1 (HIV-1) manipulates fundamental host cell processes in sophisticated ways to achieve optimum replicative efficiency. Recent studies have provided new details on the molecular interactions of HIV-1 with its host cell. For example, HIV-1 encodes a protein that regulates transcriptional elongation by interacting with a cellular cyclin-dependent kinase, another that activates the specific nuclear export of viral RNA, and several others that affect the intracellular trafficking of viral and host cell proteins. Detailed analysis of the interplay between these viral proteins and normal cellular activities has provided new insights into central questions of virology and host cell biology.

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页码：1880 / 1884

页数：5

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