Adult human hematopoietic cells provide functional hemangioblast activity

被引：61

作者：

Cogle, CR ^{[1
]}

Wainman, DA ^{[1
]}

Jorgensen, ML ^{[1
]}

Guthrie, SM ^{[1
]}

Mames, RN ^{[1
]}

Scott, EW ^{[1
]}

机构：

[1] Univ Florida, Shands Canc Ctr, Program Stem Cell Biol & Regenerat Med, Gainesville, FL 32610 USA

来源：

BLOOD | 2004年 / 103卷 / 01期

关键词：

D O I：

10.1182/blood-2003-06-2101

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The murine adult hematopoietic stem cell is able to function as a hemangioblast, contributing both to blood reconstitution and to blood vessel repair in response to ischemic injury. We developed a novel mouse xenotransplantation model of retinal neovascularization to test human hematopoietic cell plasticity. Immunocompromised nonobese diabetic (NOD)/scid mice underwent myeloablative conditioning and transplantation with human CD34(+) umbilical cord blood. After multilineage reconstitution was established, retinal ischemia was induced to promote neovascularization. Our results demonstrate human retinal neovascularization, thus revealing the functional hemangioblast activity of human hematopoietic cells.

引用

页码：133 / 135

页数：3

共 13 条

[1]

BAILEY AS, 2003, BLOOD 0904

[2] Assay of human stem cells by repopulation of NOD/SCID mice [J].

Dick, JE ;

Bhatia, M ;

Gan, O ;

Kapp, U ;

Wang, JCY .

STEM CELLS, 1997, 15 :199-203

[3]

Dick JE, 2001, ANN NY ACAD SCI, V938, P184

[4] Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization [J].

Grant, MB ;

May, WS ;

Caballero, S ;

Brown, GAJ ;

Guthrie, SM ;

Mames, RN ;

Byrne, BJ ;

Vaught, T ;

Spoerri, PE ;

Peck, AB ;

Scott, EW .

NATURE MEDICINE, 2002, 8 (06) :607-612

[5] Distinct classes of human stem cells that differ in proliferative and self-renewal potential [J].

Guenechea, G ;

Gan, OI ;

Dorrell, C ;

Dick, JE .

NATURE IMMUNOLOGY, 2001, 2 (01) :75-82

[6] In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion [J].

Ianus, A ;

Holz, GG ;

Theise, ND ;

Hussain, MA .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (06) :843-850

[7] Ex vivo expansion marginally amplifies repopulating cells from baboon peripheral blood mobilized CD34+ cells [J].

Norol, F ;

Drouet, M ;

Pflumio, F ;

Léonardi, M ;

Mourcin, F ;

Debili, N ;

Job, A ;

Vainchenker, W ;

Kuentz, M ;

Hérodin, F .

BRITISH JOURNAL OF HAEMATOLOGY, 2002, 117 (04) :924-934

[8]

Orlic D, 2002, BLOOD, V100, p28A

[9] Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors [J].

Peichev, M ;

Naiyer, AJ ;

Pereira, D ;

Zhu, ZP ;

Lane, WJ ;

Williams, M ;

Oz, MC ;

Hicklin, DJ ;

Witte, L ;

Moore, MAS ;

Rafii, S .

BLOOD, 2000, 95 (03) :952-958

[10] Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration [J].

Rafii, S ;

Lyden, D .

NATURE MEDICINE, 2003, 9 (06) :702-712

← 1 2 →