Wnt signaling: An embarrassment of receptors

被引：65

作者：

Bejsovec, A ^{[1
]}

机构：

[1] Duke Univ, Dept Biol, Durham, NC 27708 USA

来源：

CURRENT BIOLOGY | 2000年 / 10卷 / 24期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0960-9822(00)00852-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent genetic studies in Drosophila and mouse have uncovered a new aspect of the Wnt signal transduction machinery. Mutations disrupting LDL-receptor related proteins produce loss-of-function Wnt phenotypes, suggesting that these cell surface molecules may represent essential co receptors for Wnt ligands.

引用

收藏

页码：R919 / R922

页数：4

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