Upregulation of AMPA receptor GluR2 (GluA2) subunits in subcortical ischemic vascular dementia is repressed in the presence of Alzheimer's disease

被引：22

作者：

Mohamed, Nur-Ezan ^{[2
]}

Zhao, Yi ^{[3
]}

Lee, Jasinda H. ^{[2
]}

Tan, Michelle G. ^{[3
]}

Esiri, Margaret M. ^{[4
]}

Wilcock, Gordon K. ^{[4
]}

Smith, A. David ^{[4
]}

Wong, Peter T. -H. ^{[2
]}

Chen, Christopher P. ^{[2
]}

Lai, Mitchell K. P. ^{[1
,2
]}

机构：

[1] Natl Univ Singapore, Dept Pharmacol, Yong Loo Lin Sch Med, MACC,Clin Res Ctr, Singapore 117597, Singapore

[2] Natl Univ Hlth Syst, Memory Aging & Cognit Ctr, Singapore, Singapore

[3] Singapore Gen Hosp, Dept Clin Res, Singapore 0316, Singapore

[4] Univ Oxford, John Radcliffe Hosp, Oxford Project Investigate Memory & Aging OPTIMA, Oxford OX3 9DU, England

来源：

NEUROCHEMISTRY INTERNATIONAL | 2011年 / 58卷 / 07期

基金：

英国医学研究理事会;

关键词：

Alzheimer's disease; AMPA receptors; GluA2; Mixed dementia; Neocortex; Subcortical ischemic vascular dementia; TAU-PHOSPHORYLATION; GLUTAMATE; PATHOLOGY; NEUROTRANSMITTER; MODULATION; HYPOTHESIS; UPDATE; BRAIN;

D O I：

10.1016/j.neuint.2011.03.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glutamatergic AMPA receptors are of clinical significance in dementia because of their roles in mediating fast excitatory neurotransmission and other synaptic events relevant to cognition. Reductions in the AMPA receptor GluR2 subunit are well-established in Alzheimer's disease (AD), but the status of GluR2 in subcortical ischemic vascular dementia (SIVD) and mixed AD/SIVD (MIX) has not been investigated. In this study we measured GluR2 immunoreactivity and mRNA levels in the postmortem neocortex of a longitudinally assessed cohort of SIVD and MIX, together with age-matched controls. We found that GluR2 immunoreactivity and mRNA were up-regulated in SIVD, but remained unchanged in MIX. Furthermore, higher GluR2 immunoreactivity was associated with milder cognitive impairment and lower concentrations of A beta 42 peptide and phosphorylated tau. Our study suggests that GluR2 upregulation may be an adaptive process in SIVD, and that this process is repressed in the presence of concomitant AD in mixed dementia. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：820 / 825

页数：6

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