p73 is transcriptionally regulated by DNA damage, p53, and p73

被引：85

作者：

Chen, XB ^{[1
]}

Zheng, YM ^{[1
]}

Zhu, JH ^{[1
]}

Jiang, JY ^{[1
]}

Wang, J ^{[1
]}

机构：

[1] Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA

来源：

ONCOGENE | 2001年 / 20卷 / 06期

关键词：

p53; p73; DNA damage; transcriptional regulation;

D O I：

10.1038/sj.onc.1204149

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

p73 is a member of the p53 family, Recent studies have shown that DNA damage can stabilize p73 protein and enhance p73-mediated apoptosis in a c-Abl dependent manner. To determine what regulates p73 transcriptionally, we analysed the expression of p73 in several cell lines following genotoxic stresses. We found that p73 is induced in certain cell lines when treated with therapeutic DNA damaging agents. We also found that p53 and p73, but not mutant p53(R249S) and p73 beta 292, directly induce the expression of the p73 gene. In addition, we found one potential p53-binding site in the promoter of the p73 gene. This binding site is responsive to p53, p73, and DIVA damage. Taken together, these data suggest that p73 is transcriptionally regulated by DNA damage and p53, and is autoregulated.

引用

页码：769 / 774

页数：6

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