Recurrent Stroke while on Antiplatelet Therapy

被引：24

作者：

John, Seby ^{[1
]}

Katzan, Irene ^{[2
]}

机构：

[1] Cleveland Clin, Ctr Cardiovasc, Cleveland, OH 44195 USA

[2] Cleveland Clin, Neurol Inst, Ctr Outcomes Res & Evaluat, Cleveland, OH 44195 USA

来源：

NEUROLOGIC CLINICS | 2015年 / 33卷 / 02期

关键词：

Recurrence; Ischemic stroke; Antiplatelets; Resistance; Treatment failure; TRANSIENT ISCHEMIC ATTACK; PROTON-PUMP INHIBITORS; PLATELET-FUNCTION TESTS; LOW-DOSE ASPIRIN; SECONDARY PREVENTION; DOUBLE-BLIND; CEREBRAL INFARCTION; CLOPIDOGREL; RESISTANCE; ASSOCIATION;

D O I：

10.1016/j.ncl.2014.12.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Of the approximate to 795,000 strokes in the United States annually, 185,000 are recurrent. A third to half of them occur while on antiplatelet therapy. Multiple reasons could explain breakthrough stroke while on antiplatelet therapy. Management of recurrent stroke requires a meticulous search for the cause and mechanism of stroke. At present, there is no indication for antiplatelet resistance testing in ischemic stroke, or adjusting medications based on its results. Recent trials have shown the effectiveness of dual antiplatelet therapy in the acute period after an ischemic event, but no benefit has been found with this regimen for long-term secondary prevention.

引用

页码：475 / +

页数：16

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