Do human atherosclerotic lesions contain nitrotyrosine?

被引：29

作者：

Evans, P ^{[1
]}

Kaur, H ^{[1
]}

Mitchinson, MJ ^{[1
]}

Halliwell, B ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT PATHOL,CAMBRIDGE CB2 1QP,ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 226卷 / 02期

关键词：

D O I：

10.1006/bbrc.1996.1359

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitrotyrosine has been widely used as a marker of peroxynitrite formation in normal and diseased tissues. However. studies of normal human aortic intima and atherosclerotic lesions at various stages of development failed to reveal its presence except in a very few specimens of both normal and diseased tissues. The techniques used to detect nitrotyrosine-HPLC with photodiode array detection and Western blotting were able to identify nitrotyrosine after chemical nitration. Hence peroxynitrite may not be as important in the initiation of atherosclerosis as has commonly been proposed. (C) 1996 Academic Press, Inc.

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页码：346 / 351

页数：6

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