Why Helicobacter pylori has Lewis antigens

被引：89

作者：

Appelmelk, BJ

Monteiro, MA

Martin, SL

Moran, AP

Vandenbrouck-Grauls, CMJE

机构：

[1] Free Univ Amsterdam, Dept Med Microbiol, NL-1081 BT Amsterdam, Netherlands

[2] Natl Res Council Canada, Inst Biol Sci, Ottawa, ON K1A 0R6, Canada

[3] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

[4] Natl Univ Ireland Univ Coll Galway, Dept Microbiol, Galway, Ireland

来源：

TRENDS IN MICROBIOLOGY | 2000年 / 8卷 / 12期

关键词：

D O I：

10.1016/S0966-842X(00)01875-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In mimicry with human gastric epithelial cells, the lipopolysaccharide of Helicobacter pylori expresses Lewis blood group antigens. Recent data suggest that molecular mimicry does not promote immune evasion, nor does it lead to induction of autoantibodies, but that H. pylori Lewis X mediates adhesion to gastric epithelial cells and is essential for colonization.

引用

页码：565 / 570

页数：6

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