Caspases: key mediators of apoptosis

被引:388
作者
Thornberry, NA [1 ]
机构
[1] Merck & Co Inc, Merck Sharp & Dohme Res Labs, Rahway, NJ 07065 USA
来源
CHEMISTRY & BIOLOGY | 1998年 / 5卷 / 05期
关键词
D O I
10.1016/S1074-5521(98)90615-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent studies have established that members of the caspase protease family are essential components of a conserved cell death program. Insights into their biological roles, structure and mechanism are enabling investigators to begin to explore the therapeutic potential of caspase inhibition.
引用
收藏
页码:R97 / R103
页数:7
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