Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology

被引：603

作者：

Lemberger, T

Desvergne, B

Wahli, W

机构：

[1] Institut de Biologie Animale, Université de Lausanne

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 1996年 / 12卷

关键词：

adipocyte differentiation; fatty acids; insulin resistance; prostaglandins; transcription;

D O I：

10.1146/annurev.cellbio.12.1.335

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors that belong to the steroid/thyroid/retinoic acid receptor superfamily. All their characterized target genes encode proteins that participate in lipid homeostasis. The recent finding that antidiabetic thiazolidinediones and adipogenic prostanoids are ligands of one of the PPARs reveals a novel signaling pathway that directly links these compounds to processes involved in glucose homeostasis and lipid metabolism including adipocyte differentiation. A detailed understanding of this pathway could designate PPARs as targets for the development of novel efficient treatments for several metabolic disorders.

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页码：335 / +

页数：1

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