Poly (ADP-ribosyl)ation and stroke

被引：77

作者：

Chiarugi, A ^{[1
]}

机构：

[1] Univ Florence, Dept Pharmacol, I-50139 Florence, Italy

来源：

PHARMACOLOGICAL RESEARCH | 2005年 / 52卷 / 01期

关键词：

cerebral ischemia; PARP; PARG; poly(ADP-ribose); gene expression; neuroprotection;

D O I：

10.1016/j.phrs.2005.02.018

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Over the past decade, poly(ADP-ribosyl)ation has emerged as a crucial event in the pathogenesis of ischemic stroke. A large body of evidence unambiguously demonstrates that activity of poly(ADP-ribose) polymerase-1 (PARP-1) significantly increases during brain ischemia, and that inhibition of this enzymatic activity affords substantial neuroprotection from ischemic brain injury, This review strictly focuses on literature on poly (ADP-ribosyl)ation and ischemic stroke, highlighting the pathogenetic role of poly(ADP-ribose) in ischernic neuronal death, and the therapeutic relevance of drugs modulating its metabolism to pharmacological treatment of cerebral ischemia. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：15 / 24

页数：10

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