Chronic antidepressant drug treatment reduces turning behavior and increases dopamine levels in the medial prefrontal cortex

被引：34

作者：

Carlson, JN

Visker, KE

Nielsen, DM

Keller, RW

Glick, SD

机构：

[1] Dept. of Pharmacol. and Neuroscience, Albany Medical College, Albany, NY 12208

来源：

BRAIN RESEARCH | 1996年 / 707卷 / 01期

关键词：

cerebral laterality; antidepressant drug; biogenic amine; medial prefrontal cortex; nucleus accumbens; striatum;

D O I：

10.1016/0006-8993(95)01341-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of chronic administration of the antidepressant drugs desipramine, nortryptiline and paroxetine (PAR) (10 mg/kg/day, 21 days) on changes in turning (circling) behavior and on norepinephrine (NE), dopamine (DA) and serotonin and their metabolites 3,4-dihydroxyphenylacetic acid and 5-hydroxyindole acetic acid (5-HIAA) in the medial prefrontal cortex (PFC), nucleus accumbens and striatum were evaluated in rats. All three drugs eliminated turning biases in right turning rats. All drugs increased DA concentrations in the PFC while PAR increased NE in the PFC and reduced 5-HIAA in all three structures. The results are discussed with reference to previous findings involving brain asymmetry in depression.

引用

页码：122 / 126

页数：5

共 39 条

[1] EFFECTS OF LONG-TERM ADMINISTRATION OF ANTIDEPRESSANTS AND NEUROLEPTICS ON RECEPTORS IN THE CENTRAL NERVOUS-SYSTEM [J].