Risk of hospitalization for cardiovascular disease after use of macrolides and penicillins: A comparative prospective cohort study

被引：13

作者：

Ostergaard, L

Sorensen, HT

Lindholt, J

Sorensen, TE

Pedersen, L

Eriksen, T

Andersen, PL

机构：

[1] Alfred Hosp, Alfred Infect Dis Unit, Melbourne, Vic 3181, Australia

[2] Aalborg Hosp, Aalborg, Denmark

[3] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[4] Univ Aarhus, Dept Comp Sci, DK-8000 Aarhus C, Denmark

[5] Aarhus Univ Hosp, Skejby Sygehus, Dept Infect Dis & Internal Med, Aarhus, Denmark

[6] Viborg Sygehus, Dept Vasc Surg, Viborg, Denmark

来源：

JOURNAL OF INFECTIOUS DISEASES | 2001年 / 183卷 / 11期

关键词：

D O I：

10.1086/320718

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chlamydia pneumoniae has been associated with cardiovascular diseases, and C. pneumoniae infection is treatable with macrolides. In this comparative cohort study, 634 users of macrolides and 3827 users of penicillins were identified from the Danish Health Service Registry of Prescriptions and followed up for an average of 6 months. The patients were then linked to the Regional Hospital Discharge Registry to assess the outcome of hospitalization for cardiovascular disease. In the first 3 months, the relative risk (RR) of admission for a cardiovascular disease was 0.48 (95% confidence interval, 0.27-0.88) in users of macrolides compared with users of penicillins. No difference was seen after 3 months. Interaction analyses indicated that the lower risk seen in users of macrolides could be more pronounced in patients without versus those with a previous cardiovascular disease (RR, 0.39 vs. 0.52), in patients greater than or equal to 60 versus <60 years old (RR, 0.39 vs. 0.64), and in men versus women (RR, 0.35 vs. 0.67).

引用

页码：1625 / 1630

页数：6

共 21 条

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