Clathrin-binding proteins: Got a motif? Join the network!

被引：94

作者：

Dell'Angelica, EC ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA

来源：

TRENDS IN CELL BIOLOGY | 2001年 / 11卷 / 08期

关键词：

D O I：

10.1016/S0962-8924(01)02043-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Clathrin plays a key function in membrane and protein trafficking through the endocytic and late secretory pathways. Its role as a molecular scaffold that drives formation of transport vesicles requires binding to a number of proteins with distinct functional and structural properties. Recent studies have revealed that most of these proteins interact with clathrin through surprisingly simple, linear arrangements of acidic and hydrophobic amino acid residues. This article discusses the different types of clathrin-binding proteins and motifs as well as the physiological significance of these proteins in clathrin-dependent events.

引用

页码：315 / 318

页数：4

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