Prognostic role of copeptin after stroke: A systematic review and meta-analysis of observational studies

被引:37
作者
Choi, Kyu-Sun [1 ]
Kim, Hyun Jung [2 ]
Chun, Hyoung-Joon [1 ]
Kim, Jae Min [1 ]
Yi, Hyeong-Joong [1 ]
Cheong, Jin-Hwan [1 ]
Kim, Choong-Hyun [1 ]
Oh, Suck-Jun [1 ]
Ko, Yong [1 ]
Kim, Young-Soo [1 ]
Bak, Koang-Hum [1 ]
Ryu, Je-Il [1 ]
Kim, Wonhee [3 ]
Lim, Taeho [4 ]
Ahn, Hyeong Sik [2 ]
Ahn, Il Min [2 ,5 ]
Lee, Seon-Heui [6 ]
机构
[1] Hanyang Univ, Coll Med, Dept Neurosurg, Seoul 133791, South Korea
[2] Korea Univ, Coll Med, Dept Prevent Med, Seoul 136705, South Korea
[3] Hallym Univ, Coll Med, Dept Emergency Med, Seoul, South Korea
[4] Hanyang Univ, Coll Med, Dept Emergency Med, Seoul 133791, South Korea
[5] Brown Univ, Dept Literary Arts, Providence, RI 02912 USA
[6] Gachon Univ, Coll Nursing, Dept Nursing Sci, Inchon, South Korea
关键词
PLASMA COPEPTIN; ISCHEMIC-STROKE; BRAIN EDEMA; V-2; RECEPTORS; VASOPRESSIN; MORTALITY; BIOMARKERS; PRECURSOR; INJURY; DAMAGE;
D O I
10.1038/srep11665
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Copeptin, the C-terminal part of provasopressin, has emerged as a novel prognostic marker after hemorrhagic or ischemic stroke. The aim of this study was to quantitatively assess the prognostic significance of plasma copeptin level on functional outcome and mortality in patients with acute stroke using a meta-analysis of the available evidence. Thirteen relevant studies from 2,746 patients were finally included in our study. An elevated plasma copeptin level was associated with an increased risk of unfavorable outcome and mortality after stroke (OR 1.77; 95% CI, 1.44-2.19 and OR 3.90; 95% CI 3.07-4.95, respectively). The result of the pooled measure on standardized mean difference (SMD) was that plasma copeptin levels were found to be significantly higher in patients who died compared to survivors (SMD 1.70; 95% CI, 1.36-2.03). A stratified analysis by study region showed significant differences in SMD of copeptin, and the heterogeneity among studies was significantly decreased. However, the positive association of copeptin with poor prognosis after stroke was consistent in each stratified analysis. The present meta-analysis suggests that early measurement of plasma copeptin could provide better prognostic information about functional outcome and mortality in patients with acute stroke.
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页数:12
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