The CD40-CD154 interaction in B cell-T cell liaisons

被引：150

作者：

Bishop, GA ^{[1
]}

Hostager, BS

机构：

[1] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA

[2] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA

[3] Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA

[4] Vet Affairs Med Ctr, Iowa City, IA 52242 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2003年 / 14卷 / 3-4期

关键词：

B lymphocyte; T lymphocyte; TNF-R family; signal transduction;

D O I：

10.1016/S1359-6101(03)00024-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The CD40 receptor is expressed constitutively on B lymphocytes, for which it provides important signals regulating clonal expansion, antibody production and isotype switching, as well as the development of humoral memory. The major source of CD154, the ligand for CD40, is activated T lymphocytes. Interactions between CD40 and CD154 provide a number of signals that play important roles in regulating the complex and multifactorial. interactions between these two major cell types of the adaptive immune response. Understanding both the biological effects of this receptor-ligand interaction, as well as how CD40 signaling pathways are controlled, adds to our detailed picture of the complex interplay between B and T cells. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：297 / 309

页数：13

共 177 条

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