Genome maintenance mechanisms for preventing cancer

被引：3042

作者：

Hoeijmakers, JHJ ^{[1
]}

机构：

[1] Erasmus Univ, Ctr Biomed Genet, MGC Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

来源：

NATURE | 2001年 / 411卷 / 6835期

关键词：

D O I：

10.1038/35077232

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The early notion that cancer is caused by mutations in genes critical for the control of cell growth implied that genome stability is important for preventing oncogenesis. During the past decade, knowledge about the mechanisms by which genes erode and the molecular machinery designed to counteract this time-dependent genetic degeneration has increased markedly. At the same time, it has become apparent that inherited or acquired deficiencies in genome maintenance systems contribute significantly to the onset of cancer. This review summarizes the main DNA caretaking systems and their impact on genome stability and carcinogenesis.

引用

页码：366 / 374

页数：9

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