Microglia as mediators of inflammatory and degenerative diseases

被引：854

作者：

González-Scarano, F

Baltuch, G

机构：

[1] Univ Penn, Med Ctr, Dept Neurol & Microbiol, Philadelphia, PA 19104 USA

[2] Univ Penn, Med Ctr, Dept Neurosurg, Philadelphia, PA 19104 USA

来源：

ANNUAL REVIEW OF NEUROSCIENCE | 1999年 / 22卷

关键词：

human immunodeficiency virus; multiple sclerosis; Alzheimer's disease; cytokines;

D O I：

10.1146/annurev.neuro.22.1.219

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microglia are the principal immune cells in the central nervous system (CNS) and have a critical role in host defense against invading microorganisms and neoplastic cells. However, as with immune cells in other organs, microglia may play a dual role, amplifying the effects of inflammation and mediating cellular degeneration as well as protecting the CNS. In entities like human immunodeficiency virus (HIV) infection of the nervous system, microglia are also critical to viral persistence. In this review we discuss the role of microglia in three diseases in which their activity is at least partially deleterious: HIV, multiple sclerosis, and Alzheimer's disease.

引用

页码：219 / 240

页数：22

共 134 条

[1] QUANTITATION OF HUMAN-IMMUNODEFICIENCY-VIRUS, IMMUNE ACTIVATION FACTORS, AND QUINOLINIC ACID IN AIDS BRAINS [J].