Positive selection through a motif in the αβ T cell receptor

被引：98

作者：

Bäckström, BT ^{[1
]}

Müller, U ^{[1
]}

Hausmann, B ^{[1
]}

Palmer, E ^{[1
]}

机构：

[1] Basel Inst Immunol, CH-4005 Basel, Switzerland

来源：

SCIENCE | 1998年 / 281卷 / 5378期

关键词：

D O I：

10.1126/science.281.5378.835

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The two Lineages of T cells, alpha beta and gamma delta, differ in their developmental requirements: only alpha beta cells require major histocompatibility complex recognition, a process known as positive selection, The alpha beta T cell receptor (TCR), but not its gamma delta counterpart, contains a motif within the alpha-chain connecting peptide domain (alpha-CPM) that has been conserved over the Last 500 million years. In transgenic mice expressing an alpha beta TCR Lacking the alpha-CPM, thymocytes were blocked in positive selection but could undergo negative selection. Thus, the alpha-CPM seems to participate in the generation of signals required for positive selection.

引用

页码：835 / 838

页数：4

共 30 条

[1] Positive and negative selection invoke distinct signaling pathways [J].