Update on clinical trials of antiplatelet therapy for cerebrovascular diseases

被引:10
作者
Bhatt, DL
Kapadia, SR
Yadav, JS
Topol, EJ
机构
[1] Cleveland Clin Fdn, Dept Cardiol, Cleveland, OH 44195 USA
[2] Cleveland Clin Fdn, Dept Neurol, Cleveland, OH 44195 USA
关键词
aspirin; clopidogrel; dipyridamole; glycoprotein IIb/IIIa inhibitors; platelets; stroke; ticlopidine;
D O I
10.1159/000047602
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Antiplatelet medications are an important part of the therapy of cerebrovascular diseases. Oral agents such as aspirin have an established role in the secondary prevention of stroke. An aspirin and dipyridamole combination has recently been approved, Ticlopidine has been proven to be more effective than aspirin, but its poten- tially serious side effect profile makes long-term use hazardous. Clopidogrel has been demonstrated to be both more effective than and at least as safe as aspirin, The combination of clopidogrel plus aspirin represents the likely future therapy for high-risk patients. The role of oral antiplatelet therapy in the acute treatment of stroke is beginning to be clarified. Aspirin treatment appears to be strongly indicated. Intravenous antiplatelet therapy with glycoprotein IIb/IIIa inhibitors for acute stroke and as an adjunct to carotid artery stenting appears promising, Copyright (C) 2000 S. Karger AG, Basel.
引用
收藏
页码:34 / 40
页数:7
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