ICMRBS founder's medal 2006: Biological solid-state NMR, methods and applications

被引:15
作者
Baldus, Marc [1 ]
机构
[1] Max Planck Inst Biophys Chem, Res Grp Solid State NMR, D-37077 Gottingen, Germany
关键词
solid-state NMR; MAS; protein; membrane; amyloid;
D O I
10.1007/s10858-007-9177-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Solid-state NMR (ssNMR) provides increasing possibilities to study structure and dynamics of biomolecular systems. Our group has been interested in developing ssNMR-based approaches that are applicable to biomolecules of increasing molecular size and complexity without the need of specific isotope-labelling. Methodological aspects ranging from spectral assignments to the indirect detection of proton-proton contacts in multi-dimensional ssNMR are discussed and applied to (membrane) protein complexes.
引用
收藏
页码:73 / 86
页数:14
相关论文
共 132 条
[1]   NUCLEAR MAGNETIC RESONANCE SPECTRA FROM A CRYSTAL ROTATED AT HIGH SPEED [J].
ANDREW, ER ;
BRADBURY, A ;
EADES, RG .
NATURE, 1958, 182 (4650) :1659-1659
[2]   Determination of membrane protein structure and dynamics by magic-angle-spinning solid-state NMR spectroscopy [J].
Andronesi, OC ;
Becker, S ;
Seidel, K ;
Heise, H ;
Young, HS ;
Baldus, M .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (37) :12965-12974
[3]   NUCLEAR-SPIN DIFFUSION BETWEEN POLYURETHANE MICROPHASES [J].
ASSINK, RA .
MACROMOLECULES, 1978, 11 (06) :1233-1237
[4]   Protein folding monitored at individual residues during a two-dimensional NMR experiment [J].
Balbach, J ;
Forge, V ;
Lau, WS ;
vanNuland, NAJ ;
Brew, K ;
Dobson, CM .
SCIENCE, 1996, 274 (5290) :1161-1163
[5]  
Baldus M, 1998, MOL PHYS, V95, P1197, DOI 10.1080/00268979809483251
[6]   Total correlation spectroscopy in the solid state. The use of scalar couplings to determine the through-bond connectivity [J].
Baldus, M ;
Meier, BH .
JOURNAL OF MAGNETIC RESONANCE SERIES A, 1996, 121 (01) :65-69
[7]   BROAD-BAND POLARIZATION-TRANSFER EXPERIMENTS FOR ROTATING SOLIDS [J].
BALDUS, M ;
TOMASELLI, M ;
MEIER, BH ;
ERNST, RR .
CHEMICAL PHYSICS LETTERS, 1994, 230 (4-5) :329-336
[8]   Molecular interactions investigated by multi-dimensional solid-state NMR [J].
Baldus, Marc .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2006, 16 (05) :618-623
[9]   Identification of residues involved in neurotensin binding and modeling of the agonist binding site in neurotensin receptor 1 [J].
Barroso, S ;
Richard, F ;
Nicolas-Ethève, D ;
Reversat, JL ;
Bernassau, JM ;
Kitabgi, P ;
Labbé-Jullié, C .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (01) :328-336
[10]   CHEMICAL-SHIFT CORRELATION SPECTROSCOPY IN ROTATING SOLIDS - RADIO FREQUENCY-DRIVEN DIPOLAR RECOUPLING AND LONGITUDINAL EXCHANGE [J].
BENNETT, AE ;
OK, JH ;
GRIFFIN, RG ;
VEGA, S .
JOURNAL OF CHEMICAL PHYSICS, 1992, 96 (11) :8624-8627